Methadone use in a male with the FMRI premutation and FXTAS
Copyright policy )Methadone use in a male with the FMRI premutation and FXTAS
The fragile X‐associated tremor ataxia syndrome (FXTAS) is caused by the premutation in FMR1 gene. Recent reports of environmental toxins appear to worsen the progression of FXTAS. Here we present a case of male adult with FXTAS and a long history of methadone use. The patient shows a faster progression in both symptoms of disease and MRI changes compared to what is typically seen in FXTAS. There has been no research regarding the role of narcotics in onset, progression, and severity of FXTAS symptoms. However, research has shown that narcotics can have a negative impact on several neurodegenerative diseases, and we hypothesize that in this particular case, methadone may have contributed to a faster progression of FXTAS as well as exacerbating white matter disease through RNA toxicity seen in premutation carriers. © 2015 Wiley Periodicals, Inc.
- University of California, San Francisco United States
- Universitas Semarang Indonesia
- University of California Davis Medical Center United States
- Diponegoro University Indonesia
- Pennington Biomedical Research Center United States
Male, Narcotics, 570, Substance-Related Disorders, Intellectual and Developmental Disabilities (IDD), Clinical Sciences, Gene Expression, Clinical sciences, Neurodegenerative, methadone, Fragile X Mental Retardation Protein, Rare Diseases, FMR1 gene, 616, Tremor, Genetics, 2.1 Biological and endogenous factors, Humans, Fragile X Messenger Ribonucleoprotein 1, Biomedical and Clinical Sciences, Neurosciences, Middle Aged, Magnetic Resonance Imaging, White Matter, Brain Disorders, narcotics, premutation, Fragile X Syndrome, Neurological, Mutation, Disease Progression, Ataxia, FXTAS, white matter, Methadone
Male, Narcotics, 570, Substance-Related Disorders, Intellectual and Developmental Disabilities (IDD), Clinical Sciences, Gene Expression, Clinical sciences, Neurodegenerative, methadone, Fragile X Mental Retardation Protein, Rare Diseases, FMR1 gene, 616, Tremor, Genetics, 2.1 Biological and endogenous factors, Humans, Fragile X Messenger Ribonucleoprotein 1, Biomedical and Clinical Sciences, Neurosciences, Middle Aged, Magnetic Resonance Imaging, White Matter, Brain Disorders, narcotics, premutation, Fragile X Syndrome, Neurological, Mutation, Disease Progression, Ataxia, FXTAS, white matter, Methadone
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