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The microbiome meets nanotechnology: Opportunities and challenges in developing new diagnostic devices
Celia Fuentes-Chust; Claudio Parolo; Giulio Rosati; Lourdes Rivas; Karla Perez-Toralla; Stéphanie Simon; Itziar de Lecuona; +3 Authors
Celia Fuentes-Chust; Claudio Parolo; Giulio Rosati; Lourdes Rivas; Karla Perez-Toralla; Stéphanie Simon; Itziar de Lecuona; Christophe Junot; Jonel Trebicka; Arben Merkoçi;
The microbiome meets nanotechnology: Opportunities and challenges in developing new diagnostic devices
Monitoring of the human microbiome is an emerging area of diagnostics for personalized medicine. Here, the potential of different nanomaterials and nanobiosensing technologies is reviewed for the development of novel diagnostic devices for the detection and measurement of microbiome-related biomarkers. Moreover, the current and future landscape of microbiome-based diagnostics is defined by exploring the advantages and disadvantages of current nanotechnology-based approaches, especially in the context of developing point-of-care (PoC) devices that would meet the international guidelines known as REASSURED (Real-time connectivity; Ease of specimen collection; Affordability; Sensitivity; Specificity; User-friendliness; Rapid & robust operation; Equipment-free; and Deliverability). Finally, the strategies of the latest international scientific consortia working in this field are analyzed, the current microbiome diagnostics market are reported and the principal ethical, legal, and societal issues related to microbiome R&D and innovation are discussed.
The MICROB-PREDICT project has received funding from the European Union's Horizon 2020 Research & Innovation Program under grant agreement No 825694. C.P. acknowledges the Marie Skłodowska-Curie Actions Individual Fellowship; this project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 795635.
Peer reviewed
France, Spain, Spain
Microsoft Academic Graph classification: Context (language use) Personalized medicine business.industry business Precision medicine Microbiome Materials science Specimen collection Human microbiome Nanotechnology
Humans, Microbiota, Nanomedicine, Point-of-Care Systems, biomarkers, biosensors, microbiome, nanomaterials, precision medicine, [CHIM]Chemical Sciences, Mechanical Engineering, Mechanics of Materials, General Materials Science
Humans, Microbiota, Nanomedicine, Point-of-Care Systems, biomarkers, biosensors, microbiome, nanomaterials, precision medicine, [CHIM]Chemical Sciences, Mechanical Engineering, Mechanics of Materials, General Materials Science
Microsoft Academic Graph classification: Context (language use) Personalized medicine business.industry business Precision medicine Microbiome Materials science Specimen collection Human microbiome Nanotechnology
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).13 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average views 10 downloads 99 citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).13 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average - 10views99downloads
citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP!influenceInfluence provided by BIP!
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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- Université Paris Diderot France
- University of Barcelona Spain
- Autonomous University of Barcelona Spain
- FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Spain
- University of Paris-Saclay France
- Spanish National Research Council Spain
- Commissariat à l’énergie atomique et aux énergies alternatives France
- Goethe University Frankfurt Germany
Monitoring of the human microbiome is an emerging area of diagnostics for personalized medicine. Here, the potential of different nanomaterials and nanobiosensing technologies is reviewed for the development of novel diagnostic devices for the detection and measurement of microbiome-related biomarkers. Moreover, the current and future landscape of microbiome-based diagnostics is defined by exploring the advantages and disadvantages of current nanotechnology-based approaches, especially in the context of developing point-of-care (PoC) devices that would meet the international guidelines known as REASSURED (Real-time connectivity; Ease of specimen collection; Affordability; Sensitivity; Specificity; User-friendliness; Rapid & robust operation; Equipment-free; and Deliverability). Finally, the strategies of the latest international scientific consortia working in this field are analyzed, the current microbiome diagnostics market are reported and the principal ethical, legal, and societal issues related to microbiome R&D and innovation are discussed.
The MICROB-PREDICT project has received funding from the European Union's Horizon 2020 Research & Innovation Program under grant agreement No 825694. C.P. acknowledges the Marie Skłodowska-Curie Actions Individual Fellowship; this project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 795635.
Peer reviewed
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