
A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. This PM-coated nanovehicle can also effectively eliminate the circulating tumor cells in vivo and inhibit development of tumor metastasis.
Blood Platelets, Drug Carriers, Cell Membrane, Intracellular Space, Antineoplastic Agents, Nanostructures, TNF-Related Apoptosis-Inducing Ligand, Mice, Nanomedicine, Biomimetic Materials, Doxorubicin, Cell Line, Tumor, Animals, Humans
Blood Platelets, Drug Carriers, Cell Membrane, Intracellular Space, Antineoplastic Agents, Nanostructures, TNF-Related Apoptosis-Inducing Ligand, Mice, Nanomedicine, Biomimetic Materials, Doxorubicin, Cell Line, Tumor, Animals, Humans
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