In a previous communication 1 we called attention to the fact that the sensation from a sympathectomized zone of skin when exposed to cold differs considerably from that of a normally innervated zone. Seven patients were taken into a refrigerator at a temperature of 0 to 4 C. The patients were nude except for a loin cloth. They remained in the refrigerator from thirty to sixty minutes while studies of cutaneous temperature were carried out. Three patients had had a unilateral cervicodorsal ganglionectomy (removal of the inferior cervical and upper two dorsal ganglia). One had had unilateral removal of the inferior cervical and upper six dorsal ganglia. Two patients had had a unilateral splanchnicotomy and removal of the first and second lumbar ganglia. One patient had had bilateral removal of the second, third and fourth lumbar ganglia. These patients volunteered the information that the sympathectomized zone did not feel the