To the Editor.— The older dermatology literature is filled with many clinical syndromes, the manifestations of which have been astutely observed and carefully recorded, but the specific cause of which is completely unknown. We believe we may have shed some light on a possible cause of one of these entities. In October 1978, an infant came to the Indiana University Special Clinic, Indianapolis, for diagnosis of a rash present since birth. The infant was the product of an uncomplicated 36-week gestation and normal vaginal delivery. The mother had taken no medications during the pregnancy, with the exception of Iberet Filmtab vitamins, and had had no illnesses. The infant weighed 2.48 kg at birth. When the child was 8 weeks old, the skin lesions were still present but had started to fade somewhat. A local dermatologist was consulted who subsequently brought the patient and the mother to a dermatology conference where