An experiment was conducted to investigate the effects of calcium （Ca） fertilization on oxalate content in napiergrass （Pennisetum purpureum） and on some blood parameters of sheep. Re-growth napiergrass was grown with or without Ca fertilizer and offered to sheep. Eight sheep, divided into two groups of 4 animals each were used. Calcium-fertilized napiergrass was offered daily to the animals as experimental treatment, whereas without Ca-fertilized napiergrass was given to the animals as control. Results showed that there was a trend to lower soluble and total oxalate concentrations in Ca-fertilized grass than control. The Ca-fertilized grass contained （p0.05） on Ca and Na concentrations in plants. Feeding of Ca-fertilized grass had no affect on the feed consumption, blood Mg level and daily gain of sheep. However, sheep fed control grass had lower （p<0.05） blood Ca level than sheep fed Ca-fertilized grass. Our findings suggest that Ca fertilization might minimize the negative effects of oxalate.