CLINICAL CASE: COMBINATION THERAPY WITH BOSENTAN AND SILDENAFIL IN THE TREATMENT OF IDIOPATHIC PULMONARY HYPERTENSION

descriptionPublicationkeyboard_double_arrow_right Article 30 Dec 2014Publisher:Intermedservice LtdJournal:Eurasian heart journal (issn: 2225-1685, eissn: 2305-0748,

Authors: V. V. Bystrov; O. A. Arkhipova; T. V. Martynyuk; M. A. Saidova; O. V. Stukalova; N. M. Danilov; T. A. Sakhnova; +1 Authors

doi: 10.38109/2225-1685-2014-4-26-33

CLINICAL CASE: COMBINATION THERAPY WITH BOSENTAN AND SILDENAFIL IN THE TREATMENT OF IDIOPATHIC PULMONARY HYPERTENSION

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Abstract

The patient with the verified diagnosis of idiopathic pulmonary hypertension, functional class III (WHO) was treated by anticoagulants, diuretics, calcium channel blocker. After one year of adding endothelin receptor antagonist bosentan there was noticed the negative dynamic with right heart chambers dilation, appearing of heart failure signs. By 11 months of the combined pathogenetic therapy with bosentan and phosphodiesterase type 5 inhibitor sildenafil there was achieved the significant improvement of the functional and hemodynamic status. This positive dynamics remained within the next 3 years of observation.

Keywords

bosentan, антагонист рецепторов эндотелина, идиопатическая лёгочная гипертензия, ингибитор фосфодиэстеразы типа 5, sildenafil, комбинированная лаг-специфическая терапия, endothelin receptor antagonists, эндотелин-1, phosphodiesterase type 5 inhibitor, силденафил, idiopathic pulmonary hypertension, RC666-701, бозентан, Diseases of the circulatory (Cardiovascular) system

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