The features of formation and spatial differentiation of engineering-geological conditions are considered. Genetic types of soil strata are identified as followed: alluvial, lake and marsh, water-glacial, moraine. Based on the analysis of physical and mechanical properties of soils, the assessment of their use as a basement for engineering structures was conducted. It is advised to use within the Pripyat River valley loamy, sandy and sandy sediments of different genesis as natural foundations for buildings the structures. It is noted that the widespread in this area marsh sediments are extremely undesirable to use as natural foundations.