Downloads provided by UsageCountsCRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation
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L Quteineh; P-Y Bochud; D Golshayan; S Crettol; J-P Venetz; O Manuel; Z Kutalik; A Treyer; R Lehmann; N J Mueller; I Binet; C van Delden; J Steiger; P Mohacsi; J-f Dufour; P M Soccal; M Pascual; C B Eap; Rita Achermann; John-David Aubert; Philippe Baumann; Guido Beldi; Christian Benden; Christoph Berger; Isabelle Binet; Pierre-Yves Bochud; Elsa Boely; Heiner Bucher; Leo Bühler; Thierry Carell; Emmanuelle Catana; Yves Chalandon; Sabina de Geest; Olivier de Rougemont; Michael Dickenmann; Michel Duchosal; Thomas Fehr; Sylvie Ferrari-Lacraz; Christian Garzoni; Yvan Gasche; Paola Gasche Soccal; Emiliano Giostra; Déla Golshayan; Daniel Good; Karine Hadaya; Christoph Hess; Sven Hillinger; Hans Hirsch; Günther Hofbauer; Uyen Huynh-Do; Franz Immer; Richard Klaghofer; Michael Koller; Thomas Kuntzen; Bettina Laesser; Roger Lehmann; Christian Lovis; Oriol Manuel; Hans-Peter Marti; Pierre Yves Martin; Pascal Meylan; Paul Mohacsi; Isabelle Morard; Philippe Morel; Ulrike Mueller; Nicolas Mueller; Helen Mueller-McKenna; Thomas Müller; Beat Müllhaupt; David Nadal; Gayathri Nair; Manuel Pascual; Jakob Passweg; Chantal Piot Ziegler; Juliane Rick; Eddy Roosnek; Anne Rosselet; Silvia Rothlin; Frank Ruschitzka; Urs Schanz; Stefan Schaub; Christian Seiler; Nasser Semmo; Susanne Stampf; Jürg Steiger; Christian Toso; Dimitri Tsinalis; Christian Van Delden; Jean-Pierre Venetz; Jean Villard; Madeleine Wick; Markus Wilhelm; Patrick Yerly;
CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation
Metabolic syndrome after transplantation is a major concern following solid organ transplantation (SOT). The CREB-regulated transcription co-activator 2 (CRTC2) regulates glucose metabolism. The effect of CRTC2 polymorphisms on new-onset diabetes after transplantation (NODAT) was investigated in a discovery sample of SOT recipients (n1=197). Positive results were tested for replication in two samples from the Swiss Transplant Cohort Study (STCS, n2=1294 and n3=759). Obesity and other metabolic traits were also tested. Associations with metabolic traits in population-based samples (n4=46'186, n5=123'865, n6>100,000) were finally analyzed. In the discovery sample, CRTC2 rs8450-AA genotype was associated with NODAT, fasting blood glucose and body mass index (PcorrectedA was significantly associated with several metabolic abnormalities. CRTC2 rs8450G>A appears to have an important role in the high prevalence of metabolic traits observed in patients with SOT. A weak association with metabolic traits was also observed in the population-based samples.
Switzerland
- University Hospital of Basel Switzerland
- University of Bern Switzerland
- Unisanté - Centre universitaire de médecine générale et santé publique Switzerland
- University Hospital of Lausanne Switzerland
- University Hospital of Bern Switzerland
Time Factors, Organ Transplantation / adverse effects, 10234 Clinic for Infectious Diseases, Gene Frequency, Risk Factors, Odds Ratio, Prevalence, Diabetes Mellitus / genetics, Metabolic Syndrome / epidemiology, Metabolic Syndrome, Incidence, Homozygote, 10219 Clinic for Gastroenterology and Hepatology, 3004 Pharmacology, Treatment Outcome, Phenotype, 10209 Clinic for Cardiology, Diabetes Mellitus / epidemiology, 10178 Clinic for Pneumology, Metabolic Syndrome / diagnosis, Heterozygote, 610 Medicine & health, Polymorphism, Single Nucleotide, Risk Assessment, Switzerland / epidemiology, 1311 Genetics, Transcription Factors / genetics, 615, 616, Diabetes Mellitus, Humans, Diabetes Mellitus/epidemiology; Diabetes Mellitus/genetics; Dyslipidemias/epidemiology; Dyslipidemias/genetics; Gene Frequency; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Incidence; Linear Models; Logistic Models; Metabolic Syndrome X/diagnosis; Metabolic Syndrome X/epidemiology; Metabolic Syndrome X/genetics; Multivariate Analysis; Obesity/epidemiology; Obesity/genetics; Odds Ratio; Organ Transplantation/adverse effects; Phenotype; Polymorphism, Single Nucleotide; Prevalence; Risk Assessment; Risk Factors; Switzerland/epidemiology; Time Factors; Transcription Factors/genetics; Treatment Outcome, Genetic Predisposition to Disease, Obesity, Obesity / epidemiology, Obesity / genetics, Dyslipidemias, Organ Transplantation, 10020 Clinic for Cardiac Surgery, Logistic Models, Dyslipidemias / genetics, Dyslipidemias / epidemiology, 1313 Molecular Medicine, Multivariate Analysis, Linear Models, Metabolic Syndrome / genetics, ddc: ddc:616
Time Factors, Organ Transplantation / adverse effects, 10234 Clinic for Infectious Diseases, Gene Frequency, Risk Factors, Odds Ratio, Prevalence, Diabetes Mellitus / genetics, Metabolic Syndrome / epidemiology, Metabolic Syndrome, Incidence, Homozygote, 10219 Clinic for Gastroenterology and Hepatology, 3004 Pharmacology, Treatment Outcome, Phenotype, 10209 Clinic for Cardiology, Diabetes Mellitus / epidemiology, 10178 Clinic for Pneumology, Metabolic Syndrome / diagnosis, Heterozygote, 610 Medicine & health, Polymorphism, Single Nucleotide, Risk Assessment, Switzerland / epidemiology, 1311 Genetics, Transcription Factors / genetics, 615, 616, Diabetes Mellitus, Humans, Diabetes Mellitus/epidemiology; Diabetes Mellitus/genetics; Dyslipidemias/epidemiology; Dyslipidemias/genetics; Gene Frequency; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Incidence; Linear Models; Logistic Models; Metabolic Syndrome X/diagnosis; Metabolic Syndrome X/epidemiology; Metabolic Syndrome X/genetics; Multivariate Analysis; Obesity/epidemiology; Obesity/genetics; Odds Ratio; Organ Transplantation/adverse effects; Phenotype; Polymorphism, Single Nucleotide; Prevalence; Risk Assessment; Risk Factors; Switzerland/epidemiology; Time Factors; Transcription Factors/genetics; Treatment Outcome, Genetic Predisposition to Disease, Obesity, Obesity / epidemiology, Obesity / genetics, Dyslipidemias, Organ Transplantation, 10020 Clinic for Cardiac Surgery, Logistic Models, Dyslipidemias / genetics, Dyslipidemias / epidemiology, 1313 Molecular Medicine, Multivariate Analysis, Linear Models, Metabolic Syndrome / genetics, ddc: ddc:616
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