Urgency of the research. The addressed social assistance has a significant social and economic value for supporting the livelihoods of households in Ukraine. Target setting. The significance of the effective implementation of the addressed social assistance is stipulated by the need to improve the system of social security legislation and the subsidiary policy of social support of the low-income group of population. Actual scientific researches and issues analysis. V. Andriiv, N. Bolotina, N. Bublyk, O. Moskalenko, E. Libanova, O. Kuchma, S. Prylypko, B. Stashkiv, L. Shumna, N. Shpak and others were involved in the research of the effectiveness of the social and economic policy of poverty reduction and support of the low-income groups of the population. Uninvestigated parts of general matters defining. The definition of the essence of the addressed social assistance and the feasibility of introducing social inspection for monitoring the system of socio-economic support of the population remains the unsolved and not enough studied problem, as well as compliance of addressed social and economic support for the population in the form of a subsidy for separate categories of citizens. The research objective: it is necessary to substantiate that the conceptual and important direction for overcoming poverty in Ukraine is the construction of the system of social and economic support of the low-income groups of the population and to prove the necessity of reforming the appointment of subsidies to certain categories of the population. The statement of basic materials. Based on the disclosure of the impact of targeted social assistance on preventing and overcoming the poverty of the Ukrainian population, the expediency of forming a single register of recipients of assistance and services and introduction of social inspection was substantiated. It is proposed to take into account the actual amounts of income of certain categories of population for a socially fair calculation of subsidies. Conclusions. The system of adressed socio-economic support for the low-income population of Ukraine needs to be updated, taking into account the current trends, which will serve as an effective means to overcome poverty.