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Article . 2024
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AJP Gastrointestinal and Liver Physiology
Article . 2024 . Peer-reviewed
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Hepatic steatosis and not type 2 diabetes, body mass index, or hepatic fibrosis associates with hyperglucagonemia in individuals with steatotic liver disease

Authors: Sasha A. S. Kjeldsen; Mikkel P. Werge; Josephine Grandt; Michael M. Richter; Mira Thing; Liv E. Hetland; Elias B. Rashu; +9 Authors

Hepatic steatosis and not type 2 diabetes, body mass index, or hepatic fibrosis associates with hyperglucagonemia in individuals with steatotic liver disease

Abstract

Individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) present with increased plasma levels of glucagon (hyperglucagonemia), irrespective of body mass index (BMI) and type 2 diabetes. Therefore, MASLD and the resultant hyperglucagonemia may act as a diabetogenic risk factor. Notably, hepatic steatosis was a significant contributor to the hyperglucagonemia in MASLD, potentially unveiling a pathway for the hyperglucagonemia in some patients with type 2 diabetes.

Keywords

Liver/metabolism, Male, Liver Cirrhosis, Adult, Amino Acids/blood, Liver Cirrhosis/blood, Fatty Liver/blood, Middle Aged, Glucagon, Body Mass Index, Fatty Liver, Diabetes Mellitus, Type 2, Liver, Diabetes Mellitus, Humans, Glucagon/blood, Female, Obesity, Obesity/complications, Amino Acids, Diabetes Mellitus, Type 2/blood, Type 2/blood, Aged

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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