
pmid: 39104323
Individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) present with increased plasma levels of glucagon (hyperglucagonemia), irrespective of body mass index (BMI) and type 2 diabetes. Therefore, MASLD and the resultant hyperglucagonemia may act as a diabetogenic risk factor. Notably, hepatic steatosis was a significant contributor to the hyperglucagonemia in MASLD, potentially unveiling a pathway for the hyperglucagonemia in some patients with type 2 diabetes.
Liver/metabolism, Male, Liver Cirrhosis, Adult, Amino Acids/blood, Liver Cirrhosis/blood, Fatty Liver/blood, Middle Aged, Glucagon, Body Mass Index, Fatty Liver, Diabetes Mellitus, Type 2, Liver, Diabetes Mellitus, Humans, Glucagon/blood, Female, Obesity, Obesity/complications, Amino Acids, Diabetes Mellitus, Type 2/blood, Type 2/blood, Aged
Liver/metabolism, Male, Liver Cirrhosis, Adult, Amino Acids/blood, Liver Cirrhosis/blood, Fatty Liver/blood, Middle Aged, Glucagon, Body Mass Index, Fatty Liver, Diabetes Mellitus, Type 2, Liver, Diabetes Mellitus, Humans, Glucagon/blood, Female, Obesity, Obesity/complications, Amino Acids, Diabetes Mellitus, Type 2/blood, Type 2/blood, Aged
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