Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma
Copyright policy )Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma
Abstract Background Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favorable clinical outcome compared to other gliomas and a long-time survival that ranges between 10 and 20 years. However, during the course of the disease, multiple recurrences occur and the optimal treatment at each stage of the disease remains unclear. Here we report a retrospective longitudinal observation study of 836 MRI examinations in 44 ODG patients. Methods We quantified the volume of T2-hyperintensity to compute growth behavior in dependence of different treatment modalities, using various computational models. Results The identified growth pattern revealed dynamic changes, which were found to be patient-specific an did not correlate with clinical parameter or therapeutic interventions. Further, we showed that, surgical resection is beneficial for overall survival regardless the WHO grad or timepoint of surgery. To improve overall survival, an extent of resection above 50% is required. Multiple resections do not generally improve overall survival, except a greater extent of resection than in previous surgeries was achieved. Conclusions Our data aids to improve the interpretation of MRI images in clinical practice.
- RWTH Aachen University Germany
- University of Freiburg Germany
- University Medical Center Freiburg Germany
- Université Freiburg Germany
- Universitätsklinikum Aachen Germany
Adult, Male, Oligodendroglioma, 610, Astrocytoma, Segmentation, Humans, Longitudinal Studies, RC254-282, Aged, Neoplasm Staging, Aged, 80 and over, Brain Neoplasms, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Aged, 80 and over [MeSH] ; Aged [MeSH] ; MR-imaging ; Surgical oncology, cancer imaging, and interventional therapeutics ; Neoplasm Staging [MeSH] ; Astrocytoma/diagnostic imaging [MeSH] ; Male [MeSH] ; Neoplasm Recurrence, Local/diagnostic imaging [MeSH] ; Neoplasm Recurrence, Local/genetics [MeSH] ; Astrocytoma/genetics [MeSH] ; Chromosome Deletion [MeSH] ; Oligodendroglioma/diagnostic imaging [MeSH] ; Research Article ; Oligodendroglioma ; Female [MeSH] ; Follow-Up Studies [MeSH] ; Mutation [MeSH] ; Brain Neoplasms/genetics [MeSH] ; Adult [MeSH] ; Humans [MeSH] ; Longitudinal Studies [MeSH] ; Segmentation ; Retrospective Studies [MeSH] ; Middle Aged [MeSH] ; Oligodendroglioma/genetics [MeSH] ; Magnetic Resonance Imaging/methods [MeSH] ; Chromosomes, Human, Pair 19/genetics [MeSH] ; Brain Neoplasms/diagnostic imaging [MeSH] ; Chromosomes, Human, Pair 1/genetics [MeSH] ; Isocitrate Dehydrogenase/genetics [MeSH], Middle Aged, Magnetic Resonance Imaging, Isocitrate Dehydrogenase, MR-imaging, Chromosomes, Human, Pair 1, Mutation, Female, Chromosome Deletion, Neoplasm Recurrence, Local, Chromosomes, Human, Pair 19, Research Article, Follow-Up Studies
Adult, Male, Oligodendroglioma, 610, Astrocytoma, Segmentation, Humans, Longitudinal Studies, RC254-282, Aged, Neoplasm Staging, Aged, 80 and over, Brain Neoplasms, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Aged, 80 and over [MeSH] ; Aged [MeSH] ; MR-imaging ; Surgical oncology, cancer imaging, and interventional therapeutics ; Neoplasm Staging [MeSH] ; Astrocytoma/diagnostic imaging [MeSH] ; Male [MeSH] ; Neoplasm Recurrence, Local/diagnostic imaging [MeSH] ; Neoplasm Recurrence, Local/genetics [MeSH] ; Astrocytoma/genetics [MeSH] ; Chromosome Deletion [MeSH] ; Oligodendroglioma/diagnostic imaging [MeSH] ; Research Article ; Oligodendroglioma ; Female [MeSH] ; Follow-Up Studies [MeSH] ; Mutation [MeSH] ; Brain Neoplasms/genetics [MeSH] ; Adult [MeSH] ; Humans [MeSH] ; Longitudinal Studies [MeSH] ; Segmentation ; Retrospective Studies [MeSH] ; Middle Aged [MeSH] ; Oligodendroglioma/genetics [MeSH] ; Magnetic Resonance Imaging/methods [MeSH] ; Chromosomes, Human, Pair 19/genetics [MeSH] ; Brain Neoplasms/diagnostic imaging [MeSH] ; Chromosomes, Human, Pair 1/genetics [MeSH] ; Isocitrate Dehydrogenase/genetics [MeSH], Middle Aged, Magnetic Resonance Imaging, Isocitrate Dehydrogenase, MR-imaging, Chromosomes, Human, Pair 1, Mutation, Female, Chromosome Deletion, Neoplasm Recurrence, Local, Chromosomes, Human, Pair 19, Research Article, Follow-Up Studies
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