Abstract A thermally-driven bubble pump, powered by solar or waste heat energy, is a simple and efficient technique for lifting a liquid from lower to higher levels, after which it can flow by gravity. In this study, solar thermal driven pumps were incorporated in the solar collector as well as in the refrigerant cycle to provide a design of an air-conditioning system for a residential home that is independent of grid electricity. The crystallization challenge, low pressure, and low efficiency are the main downsides of bubble-pump-driven LiBr-H2O refrigeration systems, in comparison with other bubble-pump-driven diffusion absorption refrigeration systems. Therefore, a complete thermodynamic analysis of each component is necessary to improve the system performance. In this research, a thermodynamic model was developed, introducing a new absorbent-refrigerant pair (LiCl-H2O) and comparing it with LiBr-H2O, in a bubble pump operated absorption chiller driven by solar thermal energy. Under the same operating condition, the highest cooling effect and the performance of the LiCl-H2O system are 49 W and COP = 0.56 compared to 34 W and COP = 0.46 for a LiBr-H2O system.