Research on agents and multi-agent systems has matured during the last decade and many effective applications of this technology are now deployed. An international forum to present and discuss the latest scientific developments and their effective applications, to assess the impact of the approach, and to facilitate technology transfer has become a necessity and was in fact created a few years ago. PAAMS, the International Conference on Practical Applications of Agents and Multi-Agent Systems, is the international yearly platform to present, to discuss, and to disseminate the latest developments and the most important outcomes related to real-world applications. It provides a unique opportunity to bring multi-disciplinary experts, academics, and practitioners together to exchange their experience in the development and deployment of agents and multiagent systems. This volume presents the papers that were accepted for the 2013 edition of PAAMS. These articles report on the application and validation of agent-based models, methods, and technologies in a number of key application areas, including: agents for real-world Problems; crowds modelling and analysis; decision making and discovery; interaction with artificial agents; mobility, ubiquity, and clouds; (multi-)agent design technology; and simulation and organization.