
Theta burst stimulation (TBS) is a noninvasive brain stimulation technique that can be used to modulate neural networks underlying psychiatric and neurological disorders. TBS can be delivered intermittently or continuously. The conventional intermittent TBS protocol is approved by the U.S. Food and Drug Administration to treat otherwise treatment-resistant depression, but the 6-week duration limits the applicability of this therapy. Accelerated TBS protocols present an opportunity to deliver higher pulse doses in shorter periods of time, thus resulting in faster and potentially more clinically effective treatment. However, the acceleration of TBS delivery raises questions regarding the relative safety, efficacy, and durability compared with conventional TBS protocols. In this review paper, we present the data from accelerated TBS trials to date that support the safety and effectiveness of accelerated protocols while acknowledging the need for more durability data. We discuss the stimulation parameters that seem to be important for the efficacy of accelerated TBS protocols and possible avenues for further optimization.
MDD, Depressive Disorder, Theta Rhythm/physiology, Efficacy, Brain, Review, Major depressive disorder, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation/adverse effects, Depressive Disorder, Treatment-Resistant, aTBS, Treatment Outcome, Brain stimulation, Theta burst stimulation, 302065 Psychiatrie, TBS, Humans, Accelerated theta burst stimulation, Theta Rhythm, 302065 Clinical psychiatry, Treatment-Resistant/therapy
MDD, Depressive Disorder, Theta Rhythm/physiology, Efficacy, Brain, Review, Major depressive disorder, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation/adverse effects, Depressive Disorder, Treatment-Resistant, aTBS, Treatment Outcome, Brain stimulation, Theta burst stimulation, 302065 Psychiatrie, TBS, Humans, Accelerated theta burst stimulation, Theta Rhythm, 302065 Clinical psychiatry, Treatment-Resistant/therapy
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