Recent years, infrared guidance technology has more and more applications in the field of precise guidance, because it is not limited by the night or the meteorology.The development of infrared guidance technology depends on the infrared image processing technology.This paper introduces an algorithm for infrared image nonuniformity correction based in FPGA. It uses multiplication instead of division and adopts efficient pipeline technology to reduce the system logic resource usage and improve efficiency of the system.Because infrared imaging is influenced by environmental temperature, this pape proposes an infrared nonuniformity correction algorithm with the compensation if environment temperature. This algorithm is very effective to reduce the influence of the environment temperature on infrared imaging. This infrared image processing system for infrared imaging laid a foundation for the application of the infrared guidance in the field of precise guidance.