Downloads provided by UsageCountsLocus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Copyright policy )NIH| Brainstem connectomes related to Alzheimer's disease ,
UKRI| Assessing the role of the noradrenergic locus coeruleus in healthy ageing and early Alzheimer's disease ,
EC| HMRI ,
WT| Wellcome Centre for Human Neuroimaging ,
NWO| Focus on the locus network with 7Tesla MRI: from normal to impaired memory ,
NIH| Neuropathological changes underlying clinical heterogeneity in Alzheimer disease ,
WT| Restoring brain function: from cortical microcircuits to complex behaviours in neurodegenerative disease. ,
WT| unidentified ,
DFG| unidentified ,
NIH| Neuropathological changes underlying clinical heterogeneity in Alzheimer disease ,
EC| CONNECT ,
UKRI| Defining and predicting variability in early Parkinson's disease using quantitative MRI ,
EC| NISCI ,
UKRI| A new noradrenergic strategy to treat Impulsivity in Progressive Supranuclear Palsy
Betts MJ; Kirilina E; Otaduy MCG; Ivanov D; AcostaCabronero J; Callaghan MF; Lambert C; CardenasBlanco A; Pine K; Passamonti L; Loane C; Keuken MC; Trujillo P; Lüsebrink F; Mattern H; Liu KY; Priovoulos N; Fliessbach K; Dahl MJ; Maaß A; Madelung CF; Meder D; Ehrenberg AJ; Speck O; Weiskopf N; Dolan R; Inglis B; Tosun D; Morawski M; Zucca FA; Siebner HR; Mather M; Uludag K; Heinsen H; Poser BA; Howard R; Zecca L; Rowe JB; Grinberg LT; Jacobs HIL; Düzel E; Hämmerer D;
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Abstract Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations in Alzheimer’s disease, atypical neurodegenerative dementias and Parkinson’s disease. Moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. Locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. In this article, we present a consensus on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases. We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.
- Freie Universität Berlin Germany
- National Research Council Italy
- University of Copenhagen Denmark
- University of California System United States
- New York State Psychiatric Institute United States
MULTIPLE SYSTEM ATROPHY, Aging, magnetic resonance imaging (MRI), diagnostic imaging [Neurodegenerative Diseases], Neurodegenerative, metabolism [Neurodegenerative Diseases], Biomarkers/metabolism, Medical and Health Sciences, Magnetic Resonance Imaging/methods, Norepinephrine, methods [Magnetic Resonance Imaging], PARKINSONS-DISEASE, noradrenaline (NA), biomarker, 2.1 Biological and endogenous factors, magnetic resonance imaging, Locus Coeruleus/diagnostic imaging, Aetiology, screening and diagnosis, noradrenaline (NA), neurodegeneration, Neurodegenerative Diseases, COGNITIVE RESERVE, Neurodegenerative Diseases/diagnostic imaging, HUMAN BRAIN, Magnetic Resonance Imaging, ALZHEIMERS-DISEASE, Detection, HUMAN SUBSTANTIA-NIGRA, Neurological, Biomedical Imaging, biomarker, Locus Coeruleus, RELAXATION-TIMES, locus coeruleus (LC), diagnostic imaging [Locus Coeruleus], 4.2 Evaluation of markers and technologies, metabolism [Biomarkers], IN-VIVO VISUALIZATION, Norepinephrine/metabolism, 610, metabolism [Locus Coeruleus], Update, Acquired Cognitive Impairment, Humans, NEUROMELANIN, Neurology & Neurosurgery, metabolism [Norepinephrine], locus coeruleus, Psychology and Cognitive Sciences, Neurosciences, NERVOUS-SYSTEM, Brain Disorders, Locus coeruleus (LC); magnetic resonance imaging (MRI); neurodegeneration; noradrenaline (NA), noradrenaline, Dementia, Biomarkers, noradrenaline (NA) biomarker, ddc: ddc:610
MULTIPLE SYSTEM ATROPHY, Aging, magnetic resonance imaging (MRI), diagnostic imaging [Neurodegenerative Diseases], Neurodegenerative, metabolism [Neurodegenerative Diseases], Biomarkers/metabolism, Medical and Health Sciences, Magnetic Resonance Imaging/methods, Norepinephrine, methods [Magnetic Resonance Imaging], PARKINSONS-DISEASE, noradrenaline (NA), biomarker, 2.1 Biological and endogenous factors, magnetic resonance imaging, Locus Coeruleus/diagnostic imaging, Aetiology, screening and diagnosis, noradrenaline (NA), neurodegeneration, Neurodegenerative Diseases, COGNITIVE RESERVE, Neurodegenerative Diseases/diagnostic imaging, HUMAN BRAIN, Magnetic Resonance Imaging, ALZHEIMERS-DISEASE, Detection, HUMAN SUBSTANTIA-NIGRA, Neurological, Biomedical Imaging, biomarker, Locus Coeruleus, RELAXATION-TIMES, locus coeruleus (LC), diagnostic imaging [Locus Coeruleus], 4.2 Evaluation of markers and technologies, metabolism [Biomarkers], IN-VIVO VISUALIZATION, Norepinephrine/metabolism, 610, metabolism [Locus Coeruleus], Update, Acquired Cognitive Impairment, Humans, NEUROMELANIN, Neurology & Neurosurgery, metabolism [Norepinephrine], locus coeruleus, Psychology and Cognitive Sciences, Neurosciences, NERVOUS-SYSTEM, Brain Disorders, Locus coeruleus (LC); magnetic resonance imaging (MRI); neurodegeneration; noradrenaline (NA), noradrenaline, Dementia, Biomarkers, noradrenaline (NA) biomarker, ddc: ddc:610
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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