Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial
Copyright policy )Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial
Introduction Inflammation, dehydration, hypotension and bleeding may all contribute to the development of acute kidney injury (AKI). Accelerated surgery after a hip fracture can decrease the exposure time to such contributors and may reduce the risk of AKI. Methods and analysis Hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) is a multicentre, international, parallel-group randomised controlled trial (RCT). Patients who suffer a hip fracture are randomly allocated to either accelerated medical assessment and surgical repair with a goal of surgery within 6 hours of diagnosis or standard care where a repair typically occurs 24 to 48 hours after diagnosis. The primary outcome of this substudy is the development of AKI within 7 days of randomisation. We anticipate at least 1998 patients will participate in this substudy. Ethics and dissemination We obtained ethics approval for additional serum creatinine recordings in consecutive patients enrolled at 70 participating centres. All patients provide consent before randomisation. We anticipate reporting substudy results by 2021. Trial registration number NCT02027896; Pre-results.
- Wrocław Medical University Poland
- Jagiellonian University Poland
- Queen's University Canada
- University of Cape Town South Africa
- Government Medical College India
Adult, Male, accelerated surgery, ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::lesión renal aguda, Risk Assessment, Patient Care Planning, Fractures - Tractament, Time-to-Treatment, Postoperative Complications, Fracture Fixation, Risk Factors, accelerated surgery; acute kidney injury; hip fracture, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Time-to-Treatment, Humans, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Hip Fractures, Cirurgia ortopèdica, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::procedimientos ortopédicos, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Orthopedic Procedures, Acute Kidney Injury, DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injury, Insuficiència renal aguda, acute kidney injury, hip fracture, Surgery, Female, Risk Adjustment, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::tiempo hasta el tratamiento
Adult, Male, accelerated surgery, ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::lesión renal aguda, Risk Assessment, Patient Care Planning, Fractures - Tractament, Time-to-Treatment, Postoperative Complications, Fracture Fixation, Risk Factors, accelerated surgery; acute kidney injury; hip fracture, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Time-to-Treatment, Humans, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Hip Fractures, Cirurgia ortopèdica, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::procedimientos ortopédicos, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Orthopedic Procedures, Acute Kidney Injury, DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injury, Insuficiència renal aguda, acute kidney injury, hip fracture, Surgery, Female, Risk Adjustment, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::tiempo hasta el tratamiento
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