The combination of arterial hypertension (AH) with the spine pathology is a natural manifestation of connected structural-functional disorders.Aim is to determine the features of metabolic disorders in the organism of patients with hernias of lumbar spine, associated with arterial hypertension (AH), on the base of clinical-biochemical and immunological markers.Materials and methods. The study was carried out in 2016 on the base of SI “Institute of spine and joints pathology, named after prof. M.I. Sitenko, NAMS of Ukraine”. There were examined 37 patients with lumbar spine hernias: 23 – without concomitant pathologies, 14 – in association with AH of 1–2 degrees of І–ІІ stage. The control group – 30 persons, 13 men and 17 women. General protein, glycoproteins, chondroitin sulfates, C-reactive protein, glucose, urea, creatinine, β-lipoproteins, calcium, ALAT, ASAT, CPK, LDG, IL-1, IL-4 and IL-6 were determined in blood serum.Results of research. The content of interleukins in the group of patients with AH was higher than in the group of patients without it. In the group of patients with AH IL-1 was increased in 10,5 times, IL-6 – in 5,3 times that testifies to heavier immunologic disorders in patients with AH. The content of glycoproteins in patients without AH was increased by 55,8 %, in patients with AH – in 2,1 times comparing with control. The content of chondroitin sulfates in patients with hernias without AH was increased in 2,8 times, in ones with AH – in 4 times. LDG was increased, CPK – decreased in both groups. β-lipoproteins in blood of patients without concomitant AH was increased by 44,6 %, in patients with AH – by 67 %.Conclusions. In patients with lumbar spine hernias, associated with AH were observed heavier inflammatory-destructive disorders in the cartilage tissue. The increased content of β-lipoproteins in blood of patients with lumbar spine hernias, associated with AH comparing with patients without it may indicate age disorders of lipids metabolism. IL-1 and IL-6 уin patients with lumbar spine hernias, associated with AH were higher comparing with patients without it