We study the groups of local BRST cohomology associated to the general systems of ordinary differential equations, not necessarily Lagrangian or Hamiltonian. Starting with the involutive normal form of the equations, we explicitly compute certain cohomology groups having clear physical meaning. These include the groups of global symmetries, conservation laws and Lagrange structures. It is shown that the space of integrable Lagrange structures is naturally isomorphic to the space of weak Poisson brackets. The last fact allows one to establish a direct link between the path-integral quantization of general not necessarily variational dynamics by means of Lagrange structures and the deformation quantization of weak Poisson brackets.

38 pages, misprints corrected, references and the Conclusion added