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Science Signaling
Article . 2021 . Peer-reviewed
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Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation

Authors: Gu, Feng; Krüger, Aileen; Roggenkamp, Hannes G; Alpers, Rick; Lodygin, Dmitri; Jaquet, Vincent; Möckl, Franziska; +19 Authors

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation

Abstract

The enzymes DUOX1 and DUOX2 may mediate rapid and then sustained NAADP production to promote Ca 2+ signaling in T cells.

Keywords

Mice, Knockout, 570, T-Lymphocytes / enzymology, T-Lymphocytes, NADP / analogs & derivatives, 610, NADPH Oxidases, 616.07, Lymphocyte Activation, Dual Oxidases, Jurkat Cells, Mice, HEK293 Cells, NADPH Oxidases / genetics, Animals, Humans, Calcium Signaling, Dual Oxidases / genetics, NADP, NADP / biosynthesis, ddc: ddc:616.07

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    popularity
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    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
43
Top 10%
Top 10%
Top 1%
Green