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Pediatric Surgery International
Article . 2021 . Peer-reviewed
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Pediatric Surgery International
Article
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Other literature type . 2021
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https://dx.doi.org/10.25358/op...
Other literature type . 2021
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Meta-analyses in paediatric surgery are often fragile: implications and consequences

Authors: Arne Schröder; Oliver J. Muensterer; Christina Oetzmann von Sochaczewski;

Meta-analyses in paediatric surgery are often fragile: implications and consequences

Abstract

Abstract Purpose Meta-analyses occupy the highest level of evidence and thereby guide clinical decision-making. Recently, randomised-controlled trials were evaluated for the robustness of their findings by calculating the fragility index. The fragility index is the number of events that needs to be added to one treatment arm until the statistical significance collapses. We, therefore, aimed to evaluate the robustness of paediatric surgical meta-analyses. Methods We searched MEDLINE for paediatric surgical meta-analyses in the last decade. All meta-analyses on a paediatric surgical condition were eligible for analysis if they based their conclusion on a statistically significant meta-analysis. Results We screened 303 records and conducted a full-text evaluation of 60 manuscripts. Of them, 39 were included in our analysis that conducted 79 individual meta-analyses with significant results. Median fragility index was 5 (Q25–Q75% 2–11). Median fragility in relation to included patients was 0.77% (Q25–Q75% 0.29–1.87%). Conclusion Paediatric surgical meta-analyses are often fragile. In almost 60% of results, the statistical significance depends on less than 1% of the included population. However, as the fragility index is just a transformation of the P value, it basically conveys the same information in a different format. It therefore should be avoided.

Countries
Germany, Germany
Keywords

ddc:610, 610 Medizin, 610, Pediatrics, Specialties, Surgical, Original Article ; Specialties, Surgical [MeSH] ; Pediatrics [MeSH] ; Fragility index ; Fragility quotient ; Humans [MeSH] ; Randomized Controlled Trials as Topic/statistics ; Meta-analysis ; Uninformative statistic ; Surgical Procedures, Operative/statistics ; Child [MeSH], Surgical Procedures, Operative, 610 Medical sciences, Humans, Original Article, Child, Randomized Controlled Trials as Topic

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Top 10%
Top 10%
Top 10%
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hybrid