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DNA methylation as a genomic marker of exposure to chemical and environmental agents

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 01 Aug 2018 English Publisher:Elsevier BVJournal:Current Opinion in Chemical Biology, volume 45, pages 48-56 (issn: 1367-5931, Copyright policy )Funded by:UKRI | Epigenetics and Developme..., unidentified, unidentified +1 projects
Authors: Meehan; Richard R.; Thomson; John P.; Lentini; Antonio; Nestor; Coim E.; Pennings; Sari;
APC: 5,365.02 EUR

doi: 10.1016/j.cbpa.2018.02.006

pmid: 29505975

handle: 20.500.11820/08848b9f-c202-4ce6-8ed6-4cf1474e5c3b

DNA methylation as a genomic marker of exposure to chemical and environmental agents

Abstract

Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

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Keywords

Epigenomics, Epigenomics/methods, Environmental Exposure, DNA Methylation, DNA Methylation/drug effects, Epigenesis, Genetic/drug effects, Epigenesis, Genetic, Environmental Pollutants/adverse effects, Animals, Humans, Environmental Pollutants, Environmental Exposure/adverse effects

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    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 60
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
60
Top 10%
Top 10%
Top 1%
Green
hybrid
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