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Ukrainian biopharmaceutical journal
Article . 2016 . Peer-reviewed
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The antibacterial activity of complexes of Veronica longifolia herb

Authors: Kovaleva, A. M.; Osmachko, A. P.; Kashpur, N. V.; Grudko, I. V.;

The antibacterial activity of complexes of Veronica longifolia herb

Abstract

Проведено исследование антибактериальной активности двоих комплексов биологически активных веществ из травы вероники длиннолистной ‘Blaubart’ (Veronica longifolia ‘Blaubart’), полученных последовательно хлороформом и этилацетатом, по отношению к грамотрицательным (Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris) и грамположительным (Staphylococcus aureus, Bacillus subtilis) микроорганизмам, а также к Candida albicans. В комплексах выявлены иридоиды, фенольные соединения; в липофильном комплексе установлено количественное содержание каротиноидов и хлорофиллов; в фенольном комплексе установлено количественное содержание флавоноидов и гидроксикоричных кислот. Установлена высокая антибактериальная активность комплексов по отношению к Грам(-) и умеренную к Грам(+) бактериям, минимальное бактериостатическое и бактерицидное действие в дозе вдвое ниже чем препарат сравнения (2% раствор “Хлорофиллипта”).

The screening of antibacterial activity of two complexes of biologically active substances from Veronica longifolia ‘Blaubart’ herb, obtained successively by means of chloroform and ethyl acetate were conducted respect to gram-negative (Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris) and gram-positive (Staphylococcus aureus, Bacillus subtilis) microorganisms, and as well as to Candida albicans. In obtained complexes iridoids, phenolic compounds had been identified, and carotenoids and chlorophylls had been quantified in lipophilic complex, in phenolic complex – flavonoids and hydrocinnamic acids had been quantified. Complexes have shown potent antibacterial activity against Gram- and moderate activity against Gram+ bacteria, and complexes have shown minimal bacteriostatic and bactericidal effect at a dose twice lower than the comparison remedy (2% solution of Clorophylliptum).

Досліджено антибактеріальну активність двох комплексів біологічно активних речовин з трави вероніки довголистої «Blaubart» (Veronica longifolia L. «Blaubart»), отриманих послідовно хлороформом та етилацетатом, по відношенню до грамнегативних (Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris) та грампозитивних (Staphylococcus aureus, Bacillus subtilis) мікроорганізмів, а також до Candida albicans. У комплексах виявлені іридоїди, фенольні сполуки; в ліпофільному комплексі визначено вміст каротиноїдів та хлорофілів; у фенольному комплексі визначено вміст флавоноїдів та гідроксикоричних кислот. Встановлено високу антибактеріальну активність комплексів по відношенню до Грам(-) та помірну до Грам(+) бактерій, мінімальну бактеріостатичну та бактерицидну дію в дозі, яка вдвічі нижча, ніж препарат порівняння (2 % розчин «Хлорофіліпту»).

Keywords

УДК 615.281.9:615.451.1:582.916.21:579.84/.86, Вероника длиннолистная; антибактериальная активность; комплексы биологически активных веществ; грамотрицательные микроорганизмы, Вероніка довголиста; антибактеріальна активність; комплекси біологічно активних речовин; грамнегативні мікроорганізми, UDC 615.281.9:615.451.1:582.916.21:579.84/.86, Veronica longifolia; antibacterial activity; complexes of biologically active substances; gram-negative microorganisms

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
gold