Objective: Mentors are assigned to physician assistants by the heads of departments they work in after they start their duty. This study seeks to reveal physician assistants’ perceptions towards their mentors and the relationship between their such perceptions and self-efficacy.Material and Methods: The population of this study covers physician assistants working in Ege University Hospital, Izmir Atatürk Training and Research Hospital, and Izmir Tepecik Train-ing and Research Hospital. 436 of them were reached within the scope of the study. The survey method was used for data collec-tion to measure physician assistants’ perceptions of mentorship and self-efficacy. The data were analyzed using SPSS 22.0.Results: The physicians working in the training and research hospitals have a significantly higher Mentoring Functions Scale total score, significantly higher score for acceptance and confirma-tion, significantly higher score for sponsorship, and significantly higher score for exposure and visibility compared to the physicians working in the university hospital (p<0.05). The correlation analy-sis conducted between the Mentoring Functions Scale and the Self-Efficacy Scale indicated that there is a relationship between all the sub-factors except for the role modeling sub-factor of the Mentoring Functions Scale and the willingness to initiate a behav-ior sub-factor of the Self-Efficacy Scale.Conclusions: In this study, as relationships were detected be-tween persistence in the face of adversity (self-efficacy) and coach-ing and acceptance and confirmation (mentoring). Benefiting from the positive role models in physician assistants’ social milieu may not initiate a behavior but it helps to maintain a behavior.