Exposure to field vs. storage wheat dust: different consequences on respiratory symptoms and immune response among grain workers
Copyright policy )Exposure to field vs. storage wheat dust: different consequences on respiratory symptoms and immune response among grain workers
The aim of this study was to understand the differential acute effects of two distinct wheat-related dusts, such as field or stored wheat dust handling, on workers' health and how those effects evolved at 6 month intervals.Exposure, work-related symptoms, changes in lung function, and blood samples of 81 workers handling wheat and 61 controls were collected during the high exposure season and 6 months after. Specific IgG, IgE, and precipitins against 12 fungi isolated from wheat dust were titrated by enzyme-linked immunosorbent assay, dissociation-enhanced lanthanide fluorescence immunoassay, and electrosyneresis. The level of fungi was determined in the workers' environment. Levels of exhaled fraction of nitrogen monoxide (FENO) and total IgE were obtained. Exposure response associations were investigated by mixed logistic and linear regression models.The recent exposure to field wheat dust was associated with a higher prevalence for five of six self-reported airway symptoms and with a lower FENO than those in the control population. Exposure to stored wheat dust was only associated with cough. No acute impact of exposure on respiratory function was observed. Exposure to field wheat dust led to workers' sensitization against the three field fungi Aureobasidum, Cryptococcus, and Phoma, although exposure to storage wheat dust was associated with tolerance. The level of Ig remained stable 6 months after exposure.The clinical picture of workers exposed to field or storage wheat dust differed. The systematic characterization of the aerosol microbial profile may help to understand the reasons for those differences.
- University of Lausanne Switzerland
- UNIVERSITE MARIE ET LOUIS PASTEUR France
- University of Franche-Comté France
- Institute for Work & Health Canada
- Institut National de la Recherche Scientifique Canada
Male, MESH: Air Pollutants, Respiratory Tract Diseases, MESH: Logistic Models, MESH: Respiratory Function Tests, MESH: Dust, MESH: Occupational Exposure, 630, MESH: Aerosols, environment/Health, Respiratory symptoms, Longitudinal Studies, MESH: Longitudinal Studies, MESH: Middle Aged, MESH: Enzyme-Linked Immunosorbent Assay, Dust, Grain workers, Middle Aged, MESH: Interviews as Topic, Occupational, Respiratory Function Tests, Fungal, MESH: Edible Grain, Fungi-specific immunoglobulins, MESH: Antigens, Female, Adult; Aerosols/adverse effects; Agricultural Workers' Diseases/etiology; Agricultural Workers' Diseases/physiopathology; Air Pollutants, Occupational/adverse effects; Antigens, Fungal/blood; Dust/analysis; Edible Grain; Enzyme-Linked Immunosorbent Assay; Female; Fungi; Humans; Interviews as Topic; Logistic Models; Longitudinal Studies; Male; Middle Aged; Nitric Oxide/analysis; Occupational Exposure/adverse effects; Occupational Exposure/analysis; Respiratory Function Tests; Respiratory Tract Diseases/etiology; Respiratory Tract Diseases/physiopathology; Switzerland; Triticum/adverse effects; Cattle raisers; Fungi-specific immunoglobulins; Grain workers; Occupational wheat dust exposure; Respiratory symptoms, MESH: Fungi, Adult, Antigens, Fungal, Cattle raisers, MESH: Switzerland, MESH: Triticum, Enzyme-Linked Immunosorbent Assay, Air Pollutants, Occupational, Nitric Oxide, Interviews as Topic, Occupational Exposure, Humans, MESH: Agricultural Workers' Diseases, Aerosols, MESH: Humans, Fungi, MESH: Adult, Occupational wheat dust exposure, MESH: Male, Agricultural Workers' Diseases, Logistic Models, MESH: Nitric Oxide, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, MESH: Respiratory Tract Diseases, Edible Grain, MESH: Female
Male, MESH: Air Pollutants, Respiratory Tract Diseases, MESH: Logistic Models, MESH: Respiratory Function Tests, MESH: Dust, MESH: Occupational Exposure, 630, MESH: Aerosols, environment/Health, Respiratory symptoms, Longitudinal Studies, MESH: Longitudinal Studies, MESH: Middle Aged, MESH: Enzyme-Linked Immunosorbent Assay, Dust, Grain workers, Middle Aged, MESH: Interviews as Topic, Occupational, Respiratory Function Tests, Fungal, MESH: Edible Grain, Fungi-specific immunoglobulins, MESH: Antigens, Female, Adult; Aerosols/adverse effects; Agricultural Workers' Diseases/etiology; Agricultural Workers' Diseases/physiopathology; Air Pollutants, Occupational/adverse effects; Antigens, Fungal/blood; Dust/analysis; Edible Grain; Enzyme-Linked Immunosorbent Assay; Female; Fungi; Humans; Interviews as Topic; Logistic Models; Longitudinal Studies; Male; Middle Aged; Nitric Oxide/analysis; Occupational Exposure/adverse effects; Occupational Exposure/analysis; Respiratory Function Tests; Respiratory Tract Diseases/etiology; Respiratory Tract Diseases/physiopathology; Switzerland; Triticum/adverse effects; Cattle raisers; Fungi-specific immunoglobulins; Grain workers; Occupational wheat dust exposure; Respiratory symptoms, MESH: Fungi, Adult, Antigens, Fungal, Cattle raisers, MESH: Switzerland, MESH: Triticum, Enzyme-Linked Immunosorbent Assay, Air Pollutants, Occupational, Nitric Oxide, Interviews as Topic, Occupational Exposure, Humans, MESH: Agricultural Workers' Diseases, Aerosols, MESH: Humans, Fungi, MESH: Adult, Occupational wheat dust exposure, MESH: Male, Agricultural Workers' Diseases, Logistic Models, MESH: Nitric Oxide, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, MESH: Respiratory Tract Diseases, Edible Grain, MESH: Female
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