descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2020 English Publisher:Elsevier BVJournal:Surgical Oncology, volume 32, pages 108-114 (issn: 0960-7404,

Authors: Fougo, JL; Amendoeira, I; Brito, MJ; Correia, AP; Gonçalves, A; Honavar, M; Machado, A; +5 Authors

doi: 10.1016/j.suronc.2019.11.008

pmid: 31987574

handle: 10216/143346 , 10400.17/4725

Sentinel node total tumour load as a predictive factor for non-sentinel node status in early breast cancer patients – The porttle study

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Abstract

OSNA is a molecular assay for the detection of sentinel node metastasis. TTL emerged as a concept that seems to accurately predict the status of the NSN. Authors tried to confirm this motion. This is a retrospective and multicentric study that analyzed 2164 patients, 579 of whom had positive SN and completion AD. Logistic regression models were performed in order to identify a suitable cutoff to identify patients who benefit from AD. Univariate and multivariate regression analysis showed a relationship between TTL>30000 and the presence of NSN metastasis (OR 2.84, CI 1.99-4.08, p < 0.001). Logistic regression indicated that the cutoff of 30000 copies/μL better discriminates patients with NSN positivity and allows wide use of these criteria. This cutoff value may safely assist clinicians and patients to decide to proceed or not with an AD.

Related Organizations

Centro Hospitalar de Lisboa Central
Portugal
Universidade Lusófona do Porto
Portugal
Hospital do Espírito Santo
Portugal
University of Lisbon
Portugal

Keywords

Breast Neoplasms / surgery, Adult, Receptor, ErbB-2, Sentinel Lymph Node Biopsy*, Breast Neoplasms, Receptor, ErbB-2 / metabolism, Breast Neoplasms / metabolism, Carcinoma, Lobular / surgery, Young Adult, Breast cancer, Carcinoma, Lobular / secondary*, OSNA, Humans, Lymph Nodes / surgery, Carcinoma, Lobular / metabolism, Carcinoma, Ductal, Breast / surgery, Aged, Retrospective Studies, Carcinoma, Ductal, Breast / metabolism, Aged, 80 and over, Lymph Nodes / pathology*, Sentinel Lymph Node Biopsy, Carcinoma, Ductal, Breast, Non-sentinel node, Breast Neoplasms / pathology*, Middle Aged, HCC CIR, Prognosis, Receptors, Estrogen / metabolism, Carcinoma, Lobular, Receptors, Progesterone / metabolism, Sentinel node, Receptors, Estrogen, Lymphatic Metastasis, Carcinoma, Ductal, Breast / secondary*, Lymph Nodes / metabolism, Female, Lymph Nodes, Prediction, Receptors, Progesterone, Follow-Up Studies

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