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Biostatistics
Article
Data sources: UnpayWall
Biostatistics
Article . 2013 . Peer-reviewed
Data sources: Crossref
Biostatistics
Article . 2014
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Stochastic EM algorithm for doubly interval-censored data

Authors: Dejardin, David; LESAFFRE, Emmanuel;

Stochastic EM algorithm for doubly interval-censored data

Abstract

In clinical trials, it is frequently of interest to estimate the time between the onset of two events (e.g. duration of response in oncology). Here, we consider the case where subjects are assessed at fixed visits but the initial event and the terminating event occur in between visits. This type of data, called doubly interval censored, is often analyzed with standard survival techniques, assuming either that the survival time (between initial and terminating event) is known exactly or is single interval censored. We introduce a motivating dataset in which the interest is to evaluate the impact of the treatment on the duration of response endpoint. We review the existing approaches and discuss their limitations with respect to the characteristics of our motivating dataset. Furthermore, we propose a stochastic EM algorithm that overcomes the problems in the existing approaches. We show by simulations the finite sample properties of our approach.

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Keywords

Stochastic Processes, Cox proportional hazard; Doubly interval censored; stochastic EM algorithm, EMC NIHES-01-66-01, Breast Neoplasms, Survival Analysis, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols, Humans, Computer Simulation, Female, Algorithms, Proportional Hazards Models, Randomized Controlled Trials as Topic

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    7
    popularity
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    Top 10%
    influence
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    impulse
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Top 10%
Average
Average
bronze
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