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Seminars in Immunopathology
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Functional heterogeneity of CD4+ T cells in liver inflammation

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Aug 2021 English Publisher:Springer Science and Business Media LLCJournal:Seminars in Immunopathology, volume 43, pages 549-561 (issn: 1863-2297, eissn: 1863-2300, Copyright policy )
Authors: Franziska Muscate; Anna Woestemeier; Nicola Gagliani;

doi: 10.1007/s00281-021-00881-w

pmid: 34463867

pmc: PMC8443520

Functional heterogeneity of CD4+ T cells in liver inflammation

Abstract

AbstractCD4+ T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to their maturation stage, cytokine profile, and pro or anti-inflammatory functions, i.e., functional heterogeneity. In this review, we summarize what has been discovered so far regarding the role of the different CD4+ T cell polarization states in the progression of two prominent and still different liver inflammatory diseases: non-alcoholic steatohepatitis (NASH) and autoimmune hepatitis (AIH). Finally, the potential of CD4+ T cells as a therapeutic target in both NASH and AIH is discussed.

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Keywords

CD4-Positive T-Lymphocytes, Inflammation, Hepatitis, Autoimmune, Liver, Non-alcoholic Fatty Liver Disease, T-Lymphocytes, Humans, Review, Immunology ; Liver [MeSH] ; Non-alcoholic Fatty Liver Disease [MeSH] ; Humans [MeSH] ; CD4-Positive T-Lymphocytes [MeSH] ; Inflammation/etiology [MeSH] ; T-Lymphocytes [MeSH] ; Review ; Hepatitis, Autoimmune [MeSH] ; Internal Medicine

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 28
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
28
Top 10%
Average
Top 10%
Green
hybrid
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