Adolescence is a time of rapid growth and huge potential, but at the same time associated with the significant risks when social context has a significant impact. Sexual behavior of young people in Ukraine has undergone significant changes and is characterized by irresponsible d attitude to matters of sex. The average age of first sexual intercourse among adolescents is on average 15,1 years for boys - 14,7 years. The prevalence of premarital sex on the one hand, is a testament to the «liberalization» of sexual attitudes of young people, and on the other actualizes the problem of prevention of unwanted pregnancies and sexually transmitted infections. In the structure of cervical diseases in sexually active adolescent girls the cervical interepithelium neoplasia diagnosed in 25,83% of patients. Vaccination provides a new opportunity for the primary prevention of cervical cancer and cervical intraepithelial neoplasia. Thus, it is necessary to conduct a proper information campaign for adolescents and their families by involving non-governmental organizations, schools, and health services