Electrical stimulation in bone tissue engineering treatments
Copyright policy )Electrical stimulation in bone tissue engineering treatments
AbstractElectrical stimulation (EStim) has been shown to promote bone healing and regeneration both in animal experiments and clinical treatments. Therefore, incorporating EStim into promising new bone tissue engineering (BTE) therapies is a logical next step. The goal of current BTE research is to develop combinations of cells, scaffolds, and chemical and physical stimuli that optimize treatment outcomes. Recent studies demonstrating EStim’s positive osteogenic effects at the cellular and molecular level provide intriguing clues to the underlying mechanisms by which it promotes bone healing. In this review, we discuss results of recent in vitro and in vivo research focused on using EStim to promote bone healing and regeneration and consider possible strategies for its application to improve outcomes in BTE treatments. Technical aspects of exposing cells and tissues to EStim in in vitro and in vivo model systems are also discussed.
- Goethe University Frankfurt Germany
- Frankfurt University of Applied Sciences Germany
- Johann Wolfgang Goethe-Universitaet Germany
Bone Regeneration, MAP Kinase Signaling System, Bone and Bones [MeSH] ; In vivo ; MAP Kinase Signaling System [MeSH] ; Dental Pulp/cytology [MeSH] ; In vitro ; Inflammation [MeSH] ; Cell Movement [MeSH] ; Adenosine Triphosphate/metabolism [MeSH] ; Electric Stimulation Therapy/methods [MeSH] ; Cell Differentiation [MeSH] ; Apoptosis [MeSH] ; In Vitro Techniques [MeSH] ; Chondrogenesis [MeSH] ; Neovascularization, Physiologic [MeSH] ; Receptors, Cell Surface/metabolism [MeSH] ; Tissue Scaffolds [MeSH] ; Bone Regeneration [MeSH] ; Fracture Healing [MeSH] ; Guided Tissue Regeneration/methods [MeSH] ; Mechanotransduction, Cellular [MeSH] ; Osteogenesis [MeSH] ; Cell Proliferation [MeSH] ; Cell Adhesion [MeSH] ; Heat-Shock Proteins/metabolism [MeSH] ; Humans [MeSH] ; Reactive Oxygen Species/metabolism [MeSH] ; Review Article ; Osteoblasts [MeSH] ; Electric Stimulation/methods [MeSH] ; Bone tissue engineering ; Mesenchymal Stem Cells [MeSH] ; Membrane Microdomains [MeSH] ; Bone regeneration ; Electrical stimulation ; Signal Transduction [MeSH] ; Calcium Signaling [MeSH] ; Tissue Engineering/methods [MeSH], 610, Apoptosis, Electric Stimulation Therapy, Review Article, In Vitro Techniques, Bone and Bones, Adenosine Triphosphate, Cell Movement, 616, Cell Adhesion, Humans, Calcium Signaling, Dental Pulp, Heat-Shock Proteins, Cell Proliferation, Fracture Healing, Inflammation, ddc:610, Guided Tissue Regeneration, Cell Differentiation, Electric Stimulation, Chondrogenesis
Bone Regeneration, MAP Kinase Signaling System, Bone and Bones [MeSH] ; In vivo ; MAP Kinase Signaling System [MeSH] ; Dental Pulp/cytology [MeSH] ; In vitro ; Inflammation [MeSH] ; Cell Movement [MeSH] ; Adenosine Triphosphate/metabolism [MeSH] ; Electric Stimulation Therapy/methods [MeSH] ; Cell Differentiation [MeSH] ; Apoptosis [MeSH] ; In Vitro Techniques [MeSH] ; Chondrogenesis [MeSH] ; Neovascularization, Physiologic [MeSH] ; Receptors, Cell Surface/metabolism [MeSH] ; Tissue Scaffolds [MeSH] ; Bone Regeneration [MeSH] ; Fracture Healing [MeSH] ; Guided Tissue Regeneration/methods [MeSH] ; Mechanotransduction, Cellular [MeSH] ; Osteogenesis [MeSH] ; Cell Proliferation [MeSH] ; Cell Adhesion [MeSH] ; Heat-Shock Proteins/metabolism [MeSH] ; Humans [MeSH] ; Reactive Oxygen Species/metabolism [MeSH] ; Review Article ; Osteoblasts [MeSH] ; Electric Stimulation/methods [MeSH] ; Bone tissue engineering ; Mesenchymal Stem Cells [MeSH] ; Membrane Microdomains [MeSH] ; Bone regeneration ; Electrical stimulation ; Signal Transduction [MeSH] ; Calcium Signaling [MeSH] ; Tissue Engineering/methods [MeSH], 610, Apoptosis, Electric Stimulation Therapy, Review Article, In Vitro Techniques, Bone and Bones, Adenosine Triphosphate, Cell Movement, 616, Cell Adhesion, Humans, Calcium Signaling, Dental Pulp, Heat-Shock Proteins, Cell Proliferation, Fracture Healing, Inflammation, ddc:610, Guided Tissue Regeneration, Cell Differentiation, Electric Stimulation, Chondrogenesis
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