Topicality. In some regions about ¼ of the population suffers from venous disease (VD), and the main methods of treatment are endovascular laser coagulation (EVLC) and a traditional phlebectomy using Babcock technique though the optimization of such surgical measures demands perfection. Objective: to assess the results of EVLC and phlebectomy in VD at different stages after the performed surgical procedure and to distinguish the factors defining the efficiency of the operation. Material and methods. There were 302 patients with VD of the lower extremities (¼ of men and ¾ of women aged from 29 to 72 years) under the survey. C2, C3, C4, C5 and C6 classes of VD are established in 10%, 14%, 37%, 16% and 23% of the cases, respectively. EVLC was carried out by means of the device “Fotonika-Lika-Surgeon” (Ukraine). The patients were observed 2, 4 and 24 weeks later after the operation. Results. EVLC in the patients with VD of shins statistically authentically exceeds the efficiency of phlebectomy both 2–4 and 24 weeks later after the performed operation, and, the presence of comorbide gonarthrosis has a negative effect on the first method of surgical treatment, while the results of the second one depend on the severity of the disease, laser ablation is closely connected with the initial indicators of prostacyclinemia and the level of superficial viscous properties of venous blood serum whereas the efficiency of phlebectomy defines the module of viscoelasticity, at the same time both groups of the patients didn't differ on parallel using of the medications, but they differed considerably on the character of the complications (the development of phlebitis, paresthesias, thrombosis of deep veins after the exposure to laser beams and the appearance of seromas, hematomas and a hyperpigmentation of the skin in other cases), besides the administration of rivaroxaban and low-molecular heparins was prescribed for the representatives of the first group within the month from the moment of the operation, and for the second group — cyclo-3-fort. Conclusion. The preference should be given to EVLC in the choice of the method of surgical treatment of VD.