The problem of the article is to identify the main stages, methods, organizational structures of formation and implementation of targeted complex programs for the development of investment and innovation activities of industrial enterprises, the implementation of which will contribute to the success of strategic management of economic resources. The purpose of the article is to develop proposals for the formation and implementation of a targeted complex program for the development of investment and innovation activities of the enterprise. The object of research is the development of investment and innovation activities of the enterprise. The subject of research — theoretical provisions, methodological support, tools for the formation and implementation of targeted programs for the development of investment and innovation activities of enterprises. Structural-logical analysis, theoretical generalization, statistical-analytical analysis, expert survey method, program-target management method were used as research methods. Based on the analysis, the stages of formation and implementation of the target complex program of investment and innovation activities of the enterprise are proposed, which include: competitive selection and appointment of responsible executors, identification of existing problems of investment and innovation activities and their complex analysis, formulation of the main objectives of the program and their structuring by hierarchical dependence, definition and development of measures to achieve alternative goals, formation of program options taking into account alternative measures, substantiation of financial and human resources according to the established criteria for program implementation, discussion and approval, coordination of program measures and volumes of financing with the existing plan of development of the enterprise for the corresponding certain term. For each proposed stage, a study was conducted on the example of 21 machine-building enterprises for 2015—2019, which proved the feasibility of the developed proposals. The practical orientation of the research results is confirmed by the calculations for the developed complex program of investment and innovation activities for the machine-building enterprise using real data and comparison of the expected results of the program with the actual ones, which testified to the growth of investment and innovation activities.