Embryonic XMab21l2 Expression Is Required for Gastrulation and Subsequent Neural Development
Copyright policy )Embryonic XMab21l2 Expression Is Required for Gastrulation and Subsequent Neural Development
Cell fate determining gene mab-21 regulates the proper establishment of neural cell fate and sensory organ identity in nematode. Mammalian homologs of mab-21 have also been implicated to play critical roles in mid-, hindbrain and craniofacial differentiation. We report here the isolation of a mab-21 homolog, XMab21l2, from Xenopus. We showed that its expression in Xenopus was initiated at gastrulation and prominent signal was detected in neurulating embryos at the neural tube, the optic tissue, the developing midbrain, and the pharyngeal pouches. We demonstrated by RNA interference (RNAi), together with other antisense approaches, that XMab21l2 expression is required for the completion of gastrulation and subsequent neural development.
- Hong Kong Polytechnic University China (People's Republic of)
- University of Hong Kong China (People's Republic of)
- Hospital Authority China (People's Republic of)
- Queen Elizabeth Hospital China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
Embryonic expression, Double-Stranded - pharmacology, RNA - genetics - metabolism, Embryo, Nonmammalian, Developmental - drug effects, DNA - chemistry - genetics - isolation & purification, Xenopus, Molecular Sequence Data, Sequence Homology, RNA, Messenger - pharmacology, Embryonic Development, Xenopus - embryology - genetics, RNA, Antisense - pharmacology, Nervous System, Embryo, Nonmammalian - drug effects - metabolism, RNA, Double-Stranded - pharmacology, Gene Expression Regulation, Developmental - drug effects, Animals, Homeodomain Proteins - genetics, RNA, Antisense, Amino Acid Sequence, RNA, Messenger, Nervous System - embryology - metabolism, RNA, Double-Stranded, Homeodomain Proteins, Messenger - pharmacology, Sequence Homology, Amino Acid, Gastrulation, Gene Expression Regulation, Developmental, DNA, Gastrula, Sequence Analysis, DNA, Amino Acid, Phenotype, Gene Expression Regulation, Embryo, RNAi, Antisense - pharmacology, Gastrula - metabolism, Nonmammalian - drug effects - metabolism, RNA, Sequence Analysis, Sequence Alignment, XMab21l2
Embryonic expression, Double-Stranded - pharmacology, RNA - genetics - metabolism, Embryo, Nonmammalian, Developmental - drug effects, DNA - chemistry - genetics - isolation & purification, Xenopus, Molecular Sequence Data, Sequence Homology, RNA, Messenger - pharmacology, Embryonic Development, Xenopus - embryology - genetics, RNA, Antisense - pharmacology, Nervous System, Embryo, Nonmammalian - drug effects - metabolism, RNA, Double-Stranded - pharmacology, Gene Expression Regulation, Developmental - drug effects, Animals, Homeodomain Proteins - genetics, RNA, Antisense, Amino Acid Sequence, RNA, Messenger, Nervous System - embryology - metabolism, RNA, Double-Stranded, Homeodomain Proteins, Messenger - pharmacology, Sequence Homology, Amino Acid, Gastrulation, Gene Expression Regulation, Developmental, DNA, Gastrula, Sequence Analysis, DNA, Amino Acid, Phenotype, Gene Expression Regulation, Embryo, RNAi, Antisense - pharmacology, Gastrula - metabolism, Nonmammalian - drug effects - metabolism, RNA, Sequence Analysis, Sequence Alignment, XMab21l2
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