Estimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera ≥25–30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitude
Copyright policy )Estimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera ≥25–30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitude
In the absence of dose-response data, Dietary Reference Values for vitamin D in nonpregnant adults are extended to pregnancy.The aim was to estimate vitamin D intake needed to maintain maternal 25-hydroxyvitamin D [25(OH)D] in late gestation at a concentration sufficient to prevent newborn 25(OH)D 25 nmol/L. The estimated vitamin D intake required to maintain serum 25(OH)D at ≥50 nmol/L in 97.5% of women was 28.9 µg/d.Thirty micrograms of vitamin D per day safely maintained serum 25(OH)D concentrations at ≥50 nmol/L in almost all white-skinned women during pregnancy at a northern latitude, which kept 25(OH)D at >25 nmol/L in 99% and ≥30 nmol/L in 95% of umbilical cord sera. This trial was registered at www.clinicaltrials.gov as NCT02506439.
- University of Copenhagen Denmark
- University College Cork Ireland
- University of Copenhagen Denmark
- University of Copenhagen Denmark
- University of Copenhagen (UCPH) Denmark
Adult, Dietary requirements, Fetal Blood/chemistry, Vitamin D requirements, 610, Dose-Response Relationship, 618, Double-Blind Method, Pregnancy, Neonatal, Faculty of Science, Humans, /dk/atira/pure/core/keywords/TheFacultyOfScience, dietary requirements, Vitamin D, dose-response, Dose-Response Relationship, Drug, Calcium/blood, Infant, Newborn, Infant, Newborn, Fetal Blood, Vitamin D/administration & dosage, 25-hydroxyvitamin D, Dose-response, Original Research Communications, Randomized controlled trial, Parathyroid Hormone, ODIN, /dk/atira/pure/core/keywords/TheFacultyOfScience; name=Faculty of Science, Calcium, Female, Drug, Ireland
Adult, Dietary requirements, Fetal Blood/chemistry, Vitamin D requirements, 610, Dose-Response Relationship, 618, Double-Blind Method, Pregnancy, Neonatal, Faculty of Science, Humans, /dk/atira/pure/core/keywords/TheFacultyOfScience, dietary requirements, Vitamin D, dose-response, Dose-Response Relationship, Drug, Calcium/blood, Infant, Newborn, Infant, Newborn, Fetal Blood, Vitamin D/administration & dosage, 25-hydroxyvitamin D, Dose-response, Original Research Communications, Randomized controlled trial, Parathyroid Hormone, ODIN, /dk/atira/pure/core/keywords/TheFacultyOfScience; name=Faculty of Science, Calcium, Female, Drug, Ireland
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