Abstract The contingent perspective on the corporate entrepreneurship–performance relationship has focused mainly on the influence of factors either environmental or internal to the organization. Only recently have researchers turned their attention to the relational context and specifically to inter-organizational alliances’ potential to influence this relationship. Our paper analyzes how knowledge acquisition from alliances affects the corporate entrepreneurship–performance relationship in a sample of Spanish SMEs from the Information and Communication Technology sector (ICT). The results obtained show that both corporate entrepreneurship and knowledge acquisition have a positive influence on performance but that the moderating effect of knowledge acquisition on the relationship between corporate entrepreneurship and performance is negative and it varies depending on the level of knowledge-based resources of the firm.