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Towards Better Interpretability of Sepsis Prediction by Deep Neural Networks with Variable-Wise Attribution Maps

Authors: Thiboud, P.-E; Wargnier-Dauchelle, V; Lefort, M; Duchateau, N; Sdika, M;

Towards Better Interpretability of Sepsis Prediction by Deep Neural Networks with Variable-Wise Attribution Maps

Abstract

Because of the multi-symptomatic nature of sepsis, its prediction is challenging as it requires considering subtle changes in multiple monitored variables across time. Recent works based on deep neural networks improved the prediction performance, but still suffer from poor interpretability. Critical for healthcare applications, we propose to improve this aspect by separating time variables in the convolution layers of a sepsis prediction network. We reveal the improvement in interpretability capacity with the use of gradient-based attributions on high-level intermediate features and through a metric correlating the variable attribution with the prediction for perturbed pathologic samples. With 171,945 patients from the MIMIC-IV database, we demonstrate that our method not only maintains classification performances at similar network parameters count, but also substantially improves the faithfulness of per-variable attributions.

Country
France
Keywords

[INFO.INFO-AI] Computer Science [cs]/Artificial Intelligence [cs.AI], Sepsis, 616, [INFO.INFO-NE] Computer Science [cs]/Neural and Evolutionary Computing [cs.NE], Interpretability, Deep learning, [INFO.INFO-NE]Computer Science [cs]/Neural and Evolutionary Computing [cs.NE], [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], 004

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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