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Biometrical Journal
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Article . 2025
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Parametric Estimation of the Mean Number of Events in the Presence of Competing Risks

Authors: Joshua P. Entrop; Lasse H. Jakobsen; Michael J. Crowther; Mark Clements; Sandra Eloranta; Caroline E. Dietrich;

Parametric Estimation of the Mean Number of Events in the Presence of Competing Risks

Abstract

ABSTRACTRecurrent events, for example, hospitalizations or drug prescriptions, are common in time‐to‐event research. One useful summary measure of the recurrent event process is the mean number of events. Methods for estimating the mean number of events exist and are readily implemented for situations in which the recurrent event is the only possible outcome. However, estimation gets more challenging in the competing risk setting, in which methods are so far limited to nonparametric approaches. To this end, we propose a postestimation command for estimating the mean number of events in the presence of competing risks by jointly modeling the intensity function of the recurrent event and the survival function for the competing events. The proposed method is implemented in the R‐package JointFPM which is available on CRAN. Simulations demonstrate low bias and good coverage in scenarios where the intensity of the recurrent event does not depend on the number of previous events. We illustrate our method using data on readmissions after colorectal cancer surgery included in the frailtypack package for R. Estimates of the mean number of events can be used to augment time‐to‐event analyses when both recurrent and competing events exist. The proposed parametric approach offers estimation of a smooth function across time as well as easy estimation of different contrasts which is not available using a nonparametric approach.

Keywords

Risk, Biometry, Models, Statistical, Patient Readmission, survival analysis, flexible parametric survival models, recurrent events, Biometry/methods, competing events, Recurrence, Humans, Patient Readmission/statistics & numerical data, Colorectal Neoplasms, Research Article

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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hybrid
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Cancer Research