Because of the general lack of multi-level hospital management collaboration performance effectiveness research, this paper proposes a multi-level hospital management Synergy Entropy-House of Quality (HoQ) Measurement Model by innovatively combining the House of Quality (HoQ) measure model with a Synergy Entropy computing principle. Triangular fuzzy functions are used to determine the importance degree parameter of each hospital management element which combined with the results from the Synergy Entropy evaluation of the hospital management elements, arrive at a comprehensive collaborative computation result for the various elements, ensuring results objectivity. Finally, the analysis of the collaborative research on multi-level hospital management demonstrated the scientific effectiveness of the hospital management Synergy Entropy-House of Quality (HoQ) Measurement Model.