Smart and sustainable urban development is one of the leading solutions for local adaptation strategies and the efficient use of resources. The Morgenstadt Global Smart Cities Initiative (MGI) is a project funded by the International Climate Initiative (IKI) of the German Federal Ministry for the Environment, Nature Conservation, and Nuclear Safety (BMU), strengthening the development and implementation of sustainable transformation processes in cities. A sectoral approach based on empirical evidence analyses the resilience and climate risks from Piura (Peru), which is strongly affected by the consequences of climate change. The initiative uses the Morgenstadt City Lab methodology to develop integrated strategies and roadmaps for sustainable urban development. It contains a multidisciplinary survey and analysis technique. The data is leveraged by applying various methods, such as workshops, expert interviews, indicator surveys, clusters, and cross-impact analyses. Within the framework, a sustainable city profile is developed, identifying possible interventions, and co-creating project ideas with various stakeholders to improve resilience and climate change adaptation potential. The proposed solutions combine ecological and resilience objectives with opportunities for social and economic innovation that sustainably support urban development. They seek to become pilot projects and agents of sustainable integration and social inclusion that support different vulnerable communities and areas in the city.