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Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe

Authors: Boccardi, Marina; Monsch, Andreas U; Nicolosi, Valentina; Sacco, Leonardo; Aerts, Liesbeth; Albanese, Emiliano; Annoni, Jean-Marie; +53 Authors

Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe

Abstract

AbstractIntroductionHarmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts.MethodsTo harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non‐academic clinicians and experts from European, US, and Australian harmonization initiatives.ResultsWith formal presentations and thematic working‐groups we defined a standard battery consistent with the U.S. Uniform DataSet, version 3, and homogeneous methodology to obtain consistent normative data across tests and languages. Adaptations consist of including two tests specific to typical Alzheimer's disease and behavioral variant frontotemporal dementia. The methodology for harmonized normative data includes consensus definition of cognitively normal controls, classification of confounding factors (age, sex, and education), and calculation of minimum sample sizes.DiscussionThis expert consensus allows harmonizing the diagnosis of neurocognitive disorders across European countries and possibly beyond.

Keywords

diagnosis, Consensus Development Conferences as Topic, standard neuropsychological assessment, 150, Datasets as Topic, Sex Factor, Neuropsychological Tests, Alzheimer&apos, cognitive assessment, 618.97, Cognition, MONTE-CARLO, Diagnosis, BEHAVIORAL VARIANT, Age Factor, Standard neuropsychological assessment, SELECTIVE REMINDING TEST, Language, 616.0757, Age Factors, standards [Neuropsychological Tests], Alzheimer's disease, ALZHEIMERS-DISEASE, Europe, diagnosi, classification [Cognitive Dysfunction], Educational Status, Neuropsychological Test, DIFFERENTIAL-DIAGNOSIS, Alzheimer’s disease, Human, 616.8, standards [Datasets as Topic], Age Factors; Cognition; Cognitive Dysfunction/classification; Cognitive Dysfunction/diagnosis; Consensus Development Conferences as Topic; Datasets as Topic/standards; Educational Status; Europe; Expert Testimony; Humans; Language; Neuropsychological Tests/standards; Sex Factors; Alzheimer's disease; cognitive assessment; diagnosis; mild cognitive impairment; mild neurocognitive disorders; standard neuropsychological assessment, 370, CONSENSUS STATEMENT, 610 Medicine & health, 128.37, s disease, Cognitive assessment, mild cognitive impairment, Sex Factors, AMNESTIC SYNDROME, 616, Humans, Cognitive Dysfunction, Alzheimer's disease; cognitive assessment; diagnosis; mild cognitive impairment; mild neurocognitive disorders; standard neuropsychological assessment, DATA SET UDS, Expert Testimony, mild neurocognitive disorder, [SCCO.NEUR] Cognitive science/Neuroscience, Mild cognitive impairment, mild neurocognitive disorders, COGNITIVE IMPAIRMENT, Educational Statu, diagnosis [Cognitive Dysfunction], Mild neurocognitive disorders, 616.89, SAMPLE-SIZE, ddc: ddc:610

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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
48
Top 1%
Top 10%
Top 1%
Green
hybrid