The geopolitics is a teory evolved in the beginning of the 20th century, part of the political geography that examines the international relations and makes scientific investigations about relationships of the countries. South America is one of the most important geopolitical zones of the World. In its future it will be very important how the countries of the southern hemisphere can utilize and make the best forms of the regional integration of economy and trade. If Amazonia will become a ’true common interest and case’, it may be an example for the (sub)regional integration of the ’most recent and soft’ problems. Such as, protection of environment and forest, protection of the biodiversity, waterpolicy etc. In this process Brazil has a very important role in the case of Amazonia. The gradual destruction of this region has diverse consequences. On the basis of these Amazonia and the thinking about the South American territory is becoming even more important.