Gnosis in thinking of Imam Khomeini (ra) is recognition of absolute reality and existential proximity to him, which is being realized and understood with an overview of plurality and unity just as politics is strategy in doctrines of Imam Khomeini (ra) and community is reorganized based on teachings of pure Islam aimed at administering the right and achievement of social justice. Now, the main question of the article is that “what are gnostic principles of political thought of Imam Khomeini (ra)?” The principles at issue in this article are: Principles of ontology, principles of anthropology and principles of epistemology. Output of this article is that politics-gnosis relationship is a maximally interactive and real relationship based on Imam Khomeini (ra)’s political and gnostic thought, centerline point of which is “perfect man”. This is referred to words like: the Prophet, Imam and leader in religious interpretations.