The article deals with the background and benefits of international inter-cluster interactions. Research shows that the cluster is the most effective form of innovative development based on the concept of innovation ecosystem, and intercluster international partnership is the most appropriate form of organization for the development of high-tech-based inter-sectoral cooperation and implementation of international projects. It is shown that the consideration of high-tech industry in the framework of the structural model as mega cluster means that the synergistic advantage can be seen only with a clear organizational structure and coordinated interaction of clusters. Analysis of necessity of inter-cluster interaction is considered on example of space industry. We propose tools for serching partners and assess the effectiveness of the scheme on the basis of inter-cluster interaction network approach and the results for the regional economy.