Over the last decades manufacturing in UK regions has been exposed to intense global competition, particularly as a consequence of trade liberalisation. At the same time, there is an increasing recognition that regions play a central role in national development, and there are mounting pressures on regions' ability to independently strategise and interconnect globally. These trends are particularly visible in the redistribution of power and funding from national to local government currently occurring through the so-called devolution deals, and through the emergence of Local Enterprise Partnerships that since 2010 have succeeded Regional Development Agencies. The renaissance of industry and manufacturing and the recognition that industry plays a central role in job creation, growth, and regions' economic recovery is also a priority in the policy agenda, with the 'Northern Powerhouse' strategy dominating the political lexicon, and setting the ambition to deliver business and enterprise growth with economic benefits for local communities. However, without adequate technology foresight and the identification of emergent technologies that may lead to innovations in practice, industrial manufacturing regions face the challenge of industrial stagnation and the threats of global outsourcing. Therefore, it is critical for regions to overcome the debilitating problem of poor innovation capabilities reinforced by the frequent overspecialisation of the knowledge infrastructure in these areas. It is also necessary to identify the technology enablers that may lead to opportunities for development and growth: the upgrading or revitalisation of businesses; the development of new business activities in areas related to the existing industries; or new industries based in new technologies. Focusing on Sheffield City Region as an internationally recognised manufacturing hub, and on the Advance Manufacturing and Materials sector, this project will generate new knowledge and procedural solutions to the extremely important issue relating to the enhancement of a region's ability to identify and exploit knowledge of technological innovations, in order to maximise competitiveness and sustainability. Working closely with firms, local enterprise partnerships, policy makers and innovation experts, the project focuses on the understanding and development of concrete regional practices and processes for identifying, transferring and integrating technological innovations. This set of practices and processes includes the identification of relevant emergent technologies, the production of visions concerning their applicability (e.g. ability to generate product, processes or business innovations), and the contextualisation and application of the knowledge produced (brokerage activities) to allow exploitation and use in practice by firms.