ROCK aims to develop an innovative, collaborative and circular systemic approach for regeneration and adaptive reuse of historic city centres. Implementing a repertoire of successful heritage-led regeneration initiatives, it will test the replicability of the spatial approach and of successful models addressing the specific needs of historic city centres. ROCK will transfer the Role Models blueprint to the Replicators, adopting a cross-disciplinary mentoring process and defining common protocols and implementation guidelines. ROCK will deliver new ways to access and experience Cultural Heritage [CH] ensuring environmental sound solutions, city branding, bottom-up participation via living labs, while increasing liveability and safety in the involved areas. ICT sensors and tools will support the concrete application of the ROCK principles and the interoperable platform will enable new ways to collect and exchange data to facilitate networking and synergies. The added value is the combination of sustainable models, integrated management plans and associated funding mechanisms based on successful financial schemes and promoting the creation of industry-driven stakeholders’ ecosystems. A monitoring tool is set up from the beginning, running during two additional years after the project lifetime. Main expected impacts deal with the achievement of effective and shared policies able to: accelerate heritage led regeneration, improve accessibility and social cohesion, increase awareness and participation in local decision making process and wider civic engagement, foster businesses and new employment opportunities. Involving 10 cities, 7 Universities, 3 networks of enterprises, 2 networks of cities and several companies and development agencies, a foundation and a charity, ROCK is able to catalyse challenges and innovative pathways across EU and beyond, addressing CH as a production and competitiveness factor and a driver for sustainable growth.