For the last decades, the seas and the oceans have become of first ecological and socio economical interests. The detection and assay of traces of chemicals is the keystone of many oceanographic problematics such as environmental monitoring or the study and forecast of spreading of chemicals in complex ecosystems (such as PAH-Polycyclic Aromatic Hydrocarbon- or pesticides). It is now well-established that the development of compact portable sensors and analyzers can be of great help to alleviate the inherent limitations of laboratory techniques in terms of both spatial and temporal resolutions. However, the conversion of bench-top systems to on field apparatus requires integrated micro-components capable of performing accurate measurement in harsh environment. The ability to quickly detect, identify and monitor (bio)-chemical species by means of integrated optical platforms of small dimension is also a major challenge in the field of Health where the development of early diagnostic tools in medicine has become an issue of great importance. Consequently in a context of growing demand for integrated sensors for environmental and biological applications, the aim of LOUISE project is to design, assess and implement an infrared (IR) micro-component sensor based on evanescent wave spectroscopy with surface enhanced IR absorption effect (SEIRA-EWS). To achieve this innovative micro-sensor, the LOUISE project will be focused on chalcogenide glasses for their technological flexibility: integrated platform with propagation in middle-IR, compatibility with CMOS technology and suitability for mass production. An important feature of this project lies in the gold plasmonic nanoantennas that will enhanced the IR absorption of targeted molecules (PAHs and biomarkers) deposited on the surface of the chalcogenide waveguide which propagates the MIR evanescent wave. Gold nanostructures in the form of an array of nanowires will be deposited on the chalcogenide waveguide to improve the IR absorption and thus the detection of the targeted molecules. Modeling will enable us to optimize the coupling between the MIR evanescent waves at the chalcogenide waveguide surface and the plasmon modes of the gold nanoantennas in order to increase the sensitivity and the resolution of the sensor. Then, the gold nanoantennas will be functionalized with a layer of polymer or antibodies to further increase the sensitivity and the specificity of the detection. The micro-component will be integrated into a portable instrument system and will be assessed for hydrocarbon and disease biomarkers/proteins detection during validation campaigns. Two compounds will be dealt with: fluoranthen, a PAH, and toluene. At the end of the project, the micro-component is expected to detect them at concentration as low as 0.1µg/L and 70µg/L respectively. For the biological compounds, we will focus on proteins that are known to be disease biomarkers such as the manganese superoxide dismutase involved in cardiovascular injury or liver cancer. Using SEIRA techniques integrated to IR micro-sensor as proposed by this project, we expect to reach some very low detection -limit of the order of 10-12 mol/L- in body fluids (plasma, saliva…), to develop a highly sensitive biosensor and to speed-up implementation. The LOUISE project offers the opportunity to a multidisciplinary French consortium to develop MIR sensors with sensitivity enhanced by advanced technology.