To achieve a more sustainable future for all, there is growing interest in the use of plant-based diets for human nutrition. Recent findings suggest that replacing animal protein-rich foods with plant-based protein sources could be associated with health benefits and successful aging. Aging is associated with a decline in muscle mass and function that leading to adverse health outcomes and poor quality of life. Thus, the quality of dietary protein has a major role in maintaining muscle health in the elderly. Although plant-based diets could have health benefits for elderly, plant proteins are less anabolic than animal-derived proteins. However, plant proteins quality could be improved by combining different plant sources, as legume and cereals, to achieve a more favorable amino acid profile. Moreover, not only protein but also plant food matrix could contribute to maintain muscle health in seniors as dietary fibres or polyunsaturated fatty acids. However, effects of plant-based diet on muscle metabolism in the elderly remain to be studied and clinical studies are needed. The main objective of the present project is to determine how increase in the share of plant foods in the diet impacts skeletal muscle mass, function and protein metabolism, as well as the main metabolic markers in elderly. A clinical study will be conducted to compare the effects of diets containing different proportions of plant foods on skeletal muscle mass and function and protein metabolism in healthy older men and women. Subsequently, omics analyses will identify molecular mechanisms and potential muscle biomarkers that could reflect metabolic changes of skeletal muscle associated to plant-based diet. Thus, our MYOVEG project will provide information about the consequences of a switch towards more plant foods on muscle health in elderly and will participate to recommendations for maintenance of muscle and global health in older men and women.