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Flexion Pulse wave: toward a mechanical chaRacterizatiOn of Blood vessels with UltraSounds
Funder: French National Research Agency (ANR)Project code: ANR-24-CE19-4425
Funder Contribution: 452,146 EUR
Description

Since the work of Thomas Young in 1808, it is well established that strain energy can be guided along a tube as a symmetric wave: it is the pulse wave created by heart beatings and felt by palpation along arteries. However, strain energy can also propagate as an antisymmetric wave, the so-called flexion pulse wave. This latter wave, although barely hidden by the first one, has never been reported up to now in blood vessels. Our long-term vision is that this new flexion pulse wave can bring a technology breakthrough in angiography, shall it be in ultrasounds, in magnetic resonance imaging, in optics or in scanner radiology. The advantage conveyed by the new flexion pulse wave when compared to the standard pulse wave is its slowness. For this reason, the estimation speed is easier, more reliable and can conduct to a more accurate biomarker of blood vessel aging and cardiovascular risks. The ambitious short-term targeted application is thus the development of an ultrasound medical device for early detection, screening and monitoring of cardiovascular risks, a major issue in the world. Already demonstrated at capillary scale level in retina and at a macroscale level in the carotid within UCBL laboratory in Lyon, this novel approach now needs clinical validation in CHU-Rennes and technologic maturation with the help of industrial partners, E-Scopics and ANSYS. This innovation strategy follows the logic of the ANR-PRCE funding.

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