We present the Monte Carlo integration code MoCaNLO, which computes cross sections and distributions for processes at high-energy colliders like the LHC at leading and next-to-leading order (NLO) in the strong and electroweak couplings. It relies on the Recola package for the calculation of matrix elements and uses Catani–Seymour dipole subtraction for the treatment of infrared singularities. It has been used for several cutting-edge calculations of NLO QCD and electroweak corrections over the last years, such as NLO QCD corrections to off-shell top–antitop-quark production in association with a pair of bottom quarks and NLO electroweak corrections to vector-boson scattering processes.